{
  "_id": "6a17f7e7acfb0bcc41da92eb",
  "Package": "mr.raps",
  "Title": "Two Sample Mendelian Randomization using Robust Adjusted Profile\nScore",
  "Version": "0.4.3",
  "Authors@R": "c(\nperson(\"Qingyuan\", \"Zhao\", , \"qingyzhao@gmail.com\", role = c(\"aut\", \"cre\")),\nperson(\"Jingshu\", \"Wang\", , \"wangjingshususan@gmail.com\", role = \"aut\")\n)",
  "Description": "Mendelian randomization is a method of identifying and\nestimating a confounded causal effect using genetic\ninstrumental variables. This packages implements methods for\ntwo-sample Mendelian randomization with summary statistics by\nusing Robust Adjusted Profile Score (RAPS). References:\nQingyuan Zhao, Jingshu Wang, Gibran Hemani, Jack Bowden, Dylan\nS. Small. Statistical inference in two-sample summary-data\nMendelian randomization using robust adjusted profile score.\n<arXiv:1801.09652>; Qingyuan Zhao, Yang Chen, Jingshu Wang,\nDylan S. Small. Powerful genome-wide design and robust\nstatistical inference in two-sample summary-data Mendelian\nrandomization. <arXiv:1804.07371>.",
  "License": "GPL-3",
  "Remotes": [
    "ropensci/rsnps"
  ],
  "Encoding": "UTF-8",
  "LazyData": "true",
  "RoxygenNote": "7.3.3",
  "Config/pak/sysreqs": "libicu-dev libssl-dev",
  "Repository": "https://remlapmot.r-universe.dev",
  "Date/Publication": "2025-10-31 13:42:44 UTC",
  "RemoteUrl": "https://github.com/qingyuanzhao/mr.raps",
  "RemoteRef": "HEAD",
  "RemoteSha": "dd79b5bd74d10b699503cdd226d70c726f11c796",
  "NeedsCompilation": "no",
  "Packaged": {
    "Date": "2026-05-28 08:03:49 UTC",
    "User": "root"
  },
  "Author": "Qingyuan Zhao [aut, cre],\nJingshu Wang [aut]",
  "Maintainer": "Qingyuan Zhao <qingyzhao@gmail.com>",
  "MD5sum": "898e75ac1df9d38f763c70016457d1fc",
  "_user": "remlapmot",
  "_type": "src",
  "_file": "mr.raps_0.4.3.tar.gz",
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  "_created": "2026-05-28T08:03:49.000Z",
  "_published": "2026-05-28T08:08:07.078Z",
  "_distro": "noble",
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    "author": "Qingyuan Zhao <qingyzhao@gmail.com>",
    "committer": "GitHub <noreply@github.com>",
    "message": "Merge pull request #17 from remlapmot/suggestions\n\nAmend `max()` to `pmax()` in 2 places",
    "time": 1761918164
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    "login": "qingyuanzhao",
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    },
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    },
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      "package": "stats",
      "role": "Imports"
    },
    {
      "package": "bumphunter",
      "role": "Suggests"
    },
    {
      "package": "TxDb.Hsapiens.UCSC.hg38.knownGene",
      "role": "Suggests"
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  ],
  "_owner": "qingyuanzhao",
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  "_updates": [
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      "week": "2025-44",
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  "_stars": 42,
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    "name": "Tom Palmer",
    "description": "Averaging statistician ... "
  },
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  ],
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      "page": "mr.raps-package",
      "title": "Two Sample Mendelian Randomization using Robust Adjusted Profile Score",
      "topics": [
        "mr.raps-package"
      ]
    },
    {
      "page": "bmi.ais",
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      "topics": [
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      "title": "\"Effect\" of Body Mass Index (BMI) on Body Mass Index (BMI)",
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    {
      "page": "bmi.cad",
      "title": "Effect of Body Mass Index (BMI) on Coronary Artery Disease (CAD)",
      "topics": [
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      "page": "cad.cad",
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      "title": "Effect of C-Reactive Protein on Coronary Artery Disease (CAD)",
      "topics": [
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    {
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      "title": "Fit a Gaussian mixture deconvolution model",
      "topics": [
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    },
    {
      "page": "lipid.cad",
      "title": "Effect of blood lipids (LDL cholesterol, HDL cholesterol, Triglycerides) on Cardiovascular disease risk",
      "topics": [
        "lipid.cad"
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    },
    {
      "page": "modal.plot",
      "title": "Modal plot to detect heterogeneity",
      "topics": [
        "modal.plot"
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      "page": "mr.raps",
      "title": "Recommended 'mr.raps' procedure",
      "topics": [
        "mr.raps"
      ]
    },
    {
      "page": "mr.raps.mle",
      "title": "Main function for RAPS (MLE weights)",
      "topics": [
        "mr.raps.mle",
        "mr.raps.mle.all",
        "mr.raps.overdispersed",
        "mr.raps.overdispersed.robust",
        "mr.raps.simple",
        "mr.raps.simple.robust"
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      "page": "mr.raps.scatterplot",
      "title": "Scatter plot with annotation",
      "topics": [
        "mr.raps.scatterplot"
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    },
    {
      "page": "mr.raps.shrinkage",
      "title": "Main function for RAPS (shrinkage weights)",
      "topics": [
        "mr.raps.shrinkage",
        "plot.mr.raps",
        "print.mr.raps"
      ]
    },
    {
      "page": "posterior.mean",
      "title": "Compute the posterior mean under spike-and-slab Gaussian prior",
      "topics": [
        "posterior.mean"
      ]
    }
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